Revolutionary Discovery: Molecular Machines Twist DNA While Looping Chromosomes Groundbreaking Discovery by Researchers from TU Delft and IMP Vienna Biocenter Researchers from the Kavli Institute at Delft University of Technology and the IMP Vienna Biocenter have uncovered a novel characteristic of the molecular motors responsible for sha ping chromosomes. Building on their discovery six years ago that SMC motor proteins create extended loo ps in DNA, they have now revealed that these motors also introduce substantial twists within the loo ps they form. Understanding the Im pact of DNA Twisting on Chromosome Structure and Function This research enhances our understanding of chromosome structure and function, shedding light on how disru ptions in twisted DNA loo ping may contribute to health conditions such as develo pmental disorders like cohesino pathies. The findings were published in Science Advances . The Challenge of Packing DNA into the Nucleus Consider the challenge ...
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